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Friday, May 18, 2012

Hydroxycobalamin


Hydroxycobalamin is a unique form of vitamin B12, which is more readily converted into the coenzyme forms than conventional cyanocobalamin. Hydroxycobalamin also readily binds body stores of cyanide, unlike conventional cyanocobalamin, which already includes this ion in its structure.

A coenzyme is a factor needed for the effective functioning of one of the body's vital enzymes. Many vitamins, including B12, are not biologically active in the form in which they are normally found in food, but are instead used by the body as part of a coenzyme. In other words, in these cases, the body has to convert a vitamin into its coenzyme form in order for the vitamin to exert its biological function.

Or, in the case of vitamin B12: not function, but functions. The body uses vitamin B12 in the form of two different coenzymes, each of which plays a different role in the body. Adenosylcobalamin [also known as cobamamide or dibencozide], was discovered earlier, and is the better-known of these coenzymes. Methylcobalamin is the other coenzyme form of B12. Methylcobalamin prevents the creeping numbness, dementia, and spongy degeneration of the nerve cells (neurons) seen in B12 deficiency. Adenosylcobalamin helps the body to process some amino acids, and to form substances used in the body's energy cycle. One coenzyme can't substitute for the other, any more than you can use your house keys to start your car.                        

You might think that this is the kind of obscure little factoid that gets put into biology textbooks or turns up on Final Jeopardy, but which has no real-world importance. "My diet and supplement program includes plenty of B12," you might think, "so my body will make all the B12 coenzymes I could ever want or need."
Like the old song says, It ain't necessarily so. While a good diet and supplement program usually guarantees the body a generous supply of adenosylcobalamin (unless you have a deadly genetic defect), the same cannot be said of Methylcobalamin. While adenosylcobalamin is readily stored up in the liver (and, to a lesser extent, the kidneys and other tissues), methylcobalamin's job requires that it be free to circulate in body fluids like cytosol (the liquid medium of the cell), plasma, and the fluid that bathes the brain and spinal cord (cerebrospinal fluid). Because of this, Methylcobalamin doesn't hang around in the body for very long.
Thus, while a person getting enough of the basic vitamin (cobalamin) will always have plenty of adenosylcobalamin, the nervous system has no special store of protective Methylcobalamin on which to rely. In fact, the body's Methylcobalamin "fuel tanks" can easily be brought below optimal levels, and the supply is quickly depleted if it is not constantly replenished.
When you take a regular B12 (cyanocobalamin) supplement, the body must first convert its B12 into Hydroxycobalamin order to form the B12 coenzymes. This involves the removal and detoxification of the cyanide molecule, followed by biochemical reduction to a less oxidized (+1 valence) state, and then the enzymatic conversion of the reduced cobalamin into one of two metabolically active coenzyme forms. By taking a preformed Hydroxycobalamin supplement, you can skip over this first biochemical stumbling block, allowing for unhampered formation of adenosylcobalamin and Methylcobalamin.
Methylcobalamin or Hydroxycobalamin?Because the body can interconvert the two B12 coenzymes, and because the body stores adenosylcobalamin but not Methylcobalamin, an adequate supply of Methylcobalamin usually ensures that you'll have plenty of adenosylcobalamin, too - but not vice-versa. Because of this fact, and because of the powerful neuroprotective effects of Methylcobalamin, a fully-formed Methylcobalamin supplement is the best choice for most people.
One key exception is persons with known or suspected cyanide toxicity, where Hydroxycobalamin has an unique role to play. Hydroxycobalamin helps the body to rid itself of cyanide, both by reacting with the toxin to form cyanocobalamin (which can then be excreted) and by enhancing the detoxification of cyanide through its conversion into the less toxic thiocyanate. In isolated human cells, Hydroxycobalamin penetrates cyanide-laden cells and detoxifies the toxin directly. Hydroxycobalamin has a long history of intravenous use for acute, life-threatening cyanide toxicity (such as during industrial disasters) and is approved for this use in many European countries. At lower doses, oral Hydroxycobalamin increases the urinary excretion of thiocyanate in laboratory animals fed cyanide-containing diets. Sublingual Hydroxycobalamin is an ideal choice for a B12 supplement in persons concerned with chronic, low-level cyanide toxicity.




60 Sublingual Lozenges
100% Vegetarian
SUPPLEMENT FACTS:
Serving Size: 1 Lozenge


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ORTHO-BONE - AOR




Available at VITAMIN WAGON


Advanced Orthomolecular Research (AOR) has an established reputation in Canada as the most advanced supplement formulator in the country and likely, the world. The company has continued to innovate over the years, consistently putting science-backed natural health products into the hands of health practitioners and into the lives of patients years ahead of their secondary acceptance by the mainstream dietary supplement industry.

ORTHO-BONE
300 Capsules


Ortho•Bone™
is a multi-nutrient combination designed to support bone health. It features ossein microcrystalline hydroxyapatite complex (MCHC Bone Meal), a lyophilized extract of bovine bone, which retains the intact microcrystalline structure of whole bone.

The MCHC in Ortho•Bone™ is derived from Australian pasture-fed, free-range livestock, not subjected to routine antibiotics or rBGH. Guaranteed free of bovine spongiform encephalopathy.*

ADULT DOSAGE:
Take up to ten capsules daily, dividing the dose among meals to facilitate maximum absorption, taking the largest single dose with the last meal or snack of the day, or as
directed by a qualified health care practitioner.

CAUTION: Persons taking anticoagulant (“blood thinning”) medications such as warfarin
(Coumadin®) must not take this supplement

Supplement Facts
Serving Size: 10 capsules

Servings Per Container: 30

Amount Per Serving % Daily Value‡

Vitamin C (as magnesium ascorbate) 90 mg 150 %
Vitamin D3 (as cholecalciferol) 1000 IU 250 %
Vitamin K2 (menatetrenone/MK-4) 120 mcg 150 %
Folate (as folic acid) 400 mcg 100 %
Vitamin B12 (as methylcobalamin) 24 mcg 400 %
Calcium (from MCHC) 1000 mg 100 %
Phosphorus (from MCHC) 455 mg 46 %
Magnesium (as magnesium aspartate, magnesium ascorbate) 420 mg 105 %
Zinc (as zinc citrate) 11 mg 73 %
Copper (as copper (II) citrate) 1 mg 50 %
Manganese (as manganese bisglycinate) 2.3 mg 115 %
Ossein Microcrystalline Hydroxyapatite Complex (MCHC) 4545mg †
Boron (from boron citrate) 700 mcg †
Silicon (from sodium metasilicate) 35 mg †

Other ingredients: hypromellose (capsule)
No longer in Ortho-Bone: Strontium 5mg
‡Daily value based on a 2000 calorie diet. †Daily Value Not Established.

AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, nuts, dairy, soy, eggs, fish or shellfish.
Main Applications
As reported by literature:
• Excellent source of calcium and other nutrients.
• Bone health.
Pregnancy / Nursing
Safe.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.



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Wednesday, May 16, 2012

Kyolic Blood Pressure Formula 109 : Vitamin Wagon


NOW BACK IN STOCK! 

KYOLIC BLOOD PRESSURE FORMULA 109  

CLICK HERE TO ORDER


KYOLIC FORMULA 109 (BLOOD PRESSURE HEALTH) 80 Capsules
  • Kyolic Aged Garlic Extract begins with 100% organically† grown garlic bulbs.
  • Aged Garlic Extract [200 mg]; Nattokinase (NSK-SD) [35 mg]; Suntheanine (L-Theanine) [12 mg] (per capsule).
  • Kyolic Formula 109 contains a unique and natural combination of Nattokinase and Suntheanine with Aged Garlic Extract to help relax and support healthy blood pressure through different pathways.*
  • Clinical studies have shown these ingredients can help support healthy blood pressure levels.*
SUGGESTED USE: Take two or more capsules with a meal twice daily.
Supplement Facts Serving Size 2 capsules
Amount per serving%Daily Value
Aged Garlic Extract†† Powder (bulb)400 mg**
Nattokinase (NSK-SD)70 mg**
Suntheanine (L-Theanine)24 mg**
**Daily Value not established

OTHER INGREDIENTS:
Gelatin, Cellulose, Silica and Magnesium Stearate (vegetable source).
Nattokinase derived from soybeans.

FREE OF: Sodium, Yeast, Dairy, Preservatives, Sugar, Gluten, Artificial Colors or Flavors.
Store in a cool, dry place with cap tight.

Keep out of reach of children.

NSK-SD is a registered trademark of Japan Bio-Science Laboratory Co., Ltd.
Suntheanine is a registered trademark of Taiyo International, Inc.
(in complance with the California Certified Organic Farmers).


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