HYDROXY B12 - AOR

 

AVAILABLE AT VITAMIN WAGON

HYDROXY B1260 Sublingual Lozenges
100% Vegetarian

Hydroxycobalamin is a unique form of vitamin B12, which is more readily converted into the coenzyme forms than conventional cyanocobalamin. Hydroxycobalamin also readily binds body stores of cyanide, unlike conventional cyanocobalamin, which already includes this ion in its structure.

A coenzyme is a factor needed for the effective functioning of one of the body's vital enzymes. Many vitamins, including B12, are not biologically active in the form in which they are normally found in food, but are instead used by the body as part of a coenzyme. In other words, in these cases, the body has to convert a vitamin into its coenzyme form in order for the vitamin to exert its biological function.

Or, in the case of vitamin B12: not function, but functions. The body uses vitamin B12 in the form of two different coenzymes, each of which plays a different role in the body. Adenosylcobalamin [also known as cobamamide or dibencozide], was discovered earlier, and is the better-known of these coenzymes. Methylcobalamin is the other coenzyme form of B12. Methylcobalamin prevents the creeping numbness, dementia, and spongy degeneration of the nerve cells (neurons) seen in B12 deficiency. Adenosylcobalamin helps the body to process some amino acids, and to form substances used in the body's energy cycle. One coenzyme can't substitute for the other, any more than you can use your house keys to start your car.                        

You might think that this is the kind of obscure little factoid that gets put into biology textbooks or turns up on Final Jeopardy, but which has no real-world importance. "My diet and supplement program includes plenty of B12," you might think, "so my body will make all the B12 coenzymes I could ever want or need."

Like the old song says, It ain't necessarily so. While a good diet and supplement program usually guarantees the body a generous supply of adenosylcobalamin (unless you have a deadly genetic defect), the same cannot be said of Methylcobalamin. While adenosylcobalamin is readily stored up in the liver (and, to a lesser extent, the kidneys and other tissues), methylcobalamin's job requires that it be free to circulate in body fluids like cytosol (the liquid medium of the cell), plasma, and the fluid that bathes the brain and spinal cord (cerebrospinal fluid). Because of this, Methylcobalamin doesn't hang around in the body for very long.

Thus, while a person getting enough of the basic vitamin (cobalamin) will always have plenty of adenosylcobalamin, the nervous system has no special store of protective Methylcobalamin on which to rely. In fact, the body's Methylcobalamin "fuel tanks" can easily be brought below optimal levels, and the supply is quickly depleted if it is not constantly replenished.

When you take a regular B12 (cyanocobalamin) supplement, the body must first convert its B12 into Hydroxycobalamin order to form the B12 coenzymes. This involves the removal and detoxification of the cyanide molecule, followed by biochemical reduction to a less oxidized (+1 valence) state, and then the enzymatic conversion of the reduced cobalamin into one of two metabolically active coenzyme forms. By taking a preformed Hydroxycobalamin supplement, you can skip over this first biochemical stumbling block, allowing for unhampered formation of adenosylcobalamin and Methylcobalamin.

Methylcobalamin or Hydroxycobalamin?

Because the body can interconvert the two B12 coenzymes, and because the body stores adenosylcobalamin but not Methylcobalamin, an adequate supply of Methylcobalamin usually ensures that you'll have plenty of adenosylcobalamin, too - but not vice-versa. Because of this fact, and because of the powerful neuroprotective effects of Methylcobalamin, a fully-formed Methylcobalamin supplement is the best choice for most people.

One key exception is persons with known or suspected cyanide toxicity, where Hydroxycobalamin has an unique role to play. Hydroxycobalamin helps the body to rid itself of cyanide, both by reacting with the toxin to form cyanocobalamin (which can then be excreted) and by enhancing the detoxification of cyanide through its conversion into the less toxic thiocyanate. In isolated human cells, Hydroxycobalamin penetrates cyanide-laden cells and detoxifies the toxin directly. Hydroxycobalamin has a long history of intravenous use for acute, life-threatening cyanide toxicity (such as during industrial disasters) and is approved for this use in many European countries. At lower doses, oral Hydroxycobalamin increases the urinary excretion of thiocyanate in laboratory animals fed cyanide-containing diets. Sublingual Hydroxycobalamin is an ideal choice for a B12 supplement in persons concerned with chronic, low-level cyanide toxicity.

60 Sublingual Lozenges
100% Vegetarian

SUPPLEMENT FACTS:
Serving Size: 1 Lozenge

Hydroxycobalamin

1000mcg

Non-medicinal ingredients: silicon dioxide, sorbitol, magnesium stearate.AOR guaranteesthat no ingredients not listed on the label have been added to the product.

Contains no wheat, gluten, nuts, dairy, soy, eggs, fish or shellfish.

Suggested Use
Take one lozenge under the tongue daily with food, or as directed by a qualified health care practitioner.

Main Applications
• Pernicious anemia.
• Superior B12 supplement.
• Cyanide toxicity.

Source
Biological fermentation.

Pregnancy / Nursing
Safe.

Cautions
None.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The information and product descriptions appearing on this website are for information purposes only, and are not intended to provide medical advice to individuals. Consult with your physician if you have any health concerns, and before initiating any new diet, exercise, supplement, or other lifestyle changes. 

~VITAMIN WAGON carries quality products at competitive prices~

Mito Charger Advanced Orthomolecular Research (AOR)

Advanced Orthomolecular Research (AOR) has an established reputation in Canada as the most advanced supplement formulator in the country and likely, the world. The company has continued to innovate over the years, consistently putting science-backed natural health products into the hands of health practitioners and into the lives of patients years ahead of their secondary acceptance by the mainstream dietary supplement industry.

Available at Vitamin Wagon

The Importance of the Mitochondria
The cell is the basis of all life, and the mitochondrion is the power plant that keeps the cell operating. A simple but effective metaphor for what is one of the most significant and complex biochemical relationships known to science. Without mitochondria, cells simply do not produce the energy(in the form of ATP) needed for the human body to function or even survive. It comes as little surprise, therefore, that any state of mitochondrial dysfunction can be associated with a host of metabolic conditions, including Type II Diabetes, Syndrome X and excessive free radical production.

The Vicious Cycle
Ironically, the mitochondria’s ability to produce ATP also results in the simultaneous production of other, unproductive metabolic by-products, particularly ROS (reactive oxygen species) free radicals. This vicious cycle is known as the mitochondrial theory of aging.

Boosting Mitochondrial Function
Many natural compounds have been shown to help support mitochondrial function, thereby helping to counteract mitochondrial dysfunction. These compounds include antioxidants like R(+)-Lipoic acid, as well as key molecules like Co-enzyme Q10, which are involved in ATP production. Vitamin B1, the herb Rhodiola Rosea, D-uridine, Gynostemma pentaphylum, oxaloacetic acid and acetyl-L-carnitine also help to support mitochondrial function through a variety of mechanisms.

The Mitochondrial Theory of Aging
Mitochondria generate damaging free radicals, and inefficient mitochondria generate even more free radicals than efficient ones. This is because more fuel is required by each mitochondrion to produce the same amount of ATP, resulting in an increased ratio of free radicals-to-ATP production. To complicate matters further, mitochondrial DNA (mtDNA) differs from regular DNA in that mtDNA has no enzymatic defense against oxidative stressors. In-vivo studies have provided evidence for the Mitochondrial Theory of Aging so conclusive that one leading researcher summarized it this way: "It is generally accepted that oxidative mitochondrial decay is a major contributor to aging.”  

Maintaining the Power Plant – With CocktailsAs we have seen, the relative clarity of the mitochondria’s role within human biochemistry is coupled with an inherent vulnerability that must be addressed if any attempt is to be made with regard to enhancing mitochondrial health. The efforts of researchers around the world have helped to create a plethora of complex nutraceutical formulations designed to enhance mitochondrial function and health from every conceivable perspective.

How It All Works
Enzyme Bypass: The theory here is to circumvent defects in the process of ATP production. ATP production involves a lipid-soluble carrier called ubiquinone. The supplemental form of ubiquinone is Co-Enzyme Q10 (Co-Q10), and studies have shown that it can expedite certain phases of ATP production by up to 200%. NAD+ is another key coenzyme that is converted into its reduced form, NADH, during ATP production. An increased ratio of NAD+/NADH helps improve ATP production, and has also been linked to the activation of genes that have been associated with anti-aging effects. Oxaloacetic acid (benaGeneTM) has been shown to increase the ratio of NAD+/NADH. It also mimics the effects of a calorie-restricted diet, which has been shown to increase life-span in several mammal species.

Antioxidants: Conventional anti-oxidants such as vitamins C and E are certainly useful, but the ideal mitochondrial antioxidant appears to be R(+)-lipoic acid. Lipoic acid is metabolized to its active form, diHydrolipoic acid (DHLA) inside the mitochondrion itself. This process produces intense biological activity, including the regeneration and recycling of vitamins C and E and enhanced insulin sensitivity.

Alternative Energy: This tactic involves the maximal utilization of a source of ATP that does not require any mitochondrial participation, thus augmenting overall ATP production without burdening dysfunctional or aging mitochondria. The herb Rhodiola rosea has demonstrated a capacity to increase ATP production.

Reducing Lactate: Lactate is a by-product of anaerobic energy production that can build up in the muscles and cause muscle cramping. Lactate is formed from pyruvate, and if pyruvate can be directed into the mitochondria and away from lactate production, it can instead be used for further energy production. This can be accomplished with vitamin B1 supplementation. This has been made even more appealing by the development of benfotiamine, which is nearly 5 times more bio-available than conventional thiamin.
Nucleotide Precursors: Nucleotides are the structural units of DNA and RNA – including mtDNA and mtRNA. As mitochondrial dysfunction is closely associated with the depletion of nucleotides, maintaining a healthy nucleotide pool is paramount. Uridine seems to be able to do this, and naturally-derived uridine supplements have been studied for their ability to improve mitochondrial function in patients with HIV.

Vasodilation: Vasodilation (the widening of the blood vessels) is linked to the mitochondria via the production of nitric oxide. The mitochondria are primary targets of nitric oxide, and even small amounts can regulate ATP synthesis. Gynostemma pentaphyllum is a powerful nitric oxide enhancer.

Fatty Acid Utilization: Acetyl-L-carnitine (ALCAR) is a source of L-carnitine, a key molecule involved in cellular energy production and that is essential for proper mitochondrial function. The most important function of Lcarnitine is to help shuttle fatty acids into the mitochondria, where they are then used as fuel for energy production. Depleted L-carnitine levels have been associated with muscle and heart dysfunction.

AOR’s Mitocharger provides an advanced and effective formula to help support the mitochondria and to counteract aging associated with mitochondrial deficiencies.

180 Vegi-Caps

Serving Size: 6 Capsules(Taken together or 2 capsules with each meal.)
R(+)-Lipoic acid 150 mg
Co-enzyme Q10 100 mg
Rhodiola Rosea 150 mg
Benfotiamine 150 mg
Oxaloacetic Acid (benaGeneTM) 100 mg
D-Uridine 50 mg
Gynostemma Pentaphyllum 100 mg
Acetyl-L-Carnitine 1500 mg

Key Features:
Advanced mitochondrial support formula

Suggested Use:
Take 6 capsules daily with food, or as directed by a qualified health care
practitioner. (Note: The 6 capsules can be spread out throughout the day.
They are to be taken with food, 2 capsules with each meal is recommended
if they will be split up throughout the day.)
Source:
Multi-Sourced

Cautions:
None Known

Pregnancy Nursing:
Do not use if pregnant or nursing

Main Applications:
Support for mitochondrial dysfunction
Type II diabetes
Syndrome X

~Vitamin Wagon carries quality products at competitive prices~

Liquid B12 (Methyl)

Available at Vitamin Wagon

Liquid B12 (Methyl) 1oz bottle

Product Highlights:
Helps protect against cancers including breast, colon, lung, and prostate cancer
Essential for healthy skin, hair, and nails
Helps in cell reproduction and constant renewal of the skin
Helps convert carbohydrates into energy

Product Information:
B-12 and folic acid, when in the Methyl form provides a very powerful duo. There are several kinds of B-12 and Folic acid and AnuMed has selected the most expensive kind (the Methyl forms for both) so that maximum bioavailability and effect are reached by those that use our dietary supplement.

Vitamin B-6 is almost always added to a B-12 formula to potentiate both the B-12 and the Folic Acid.

B-12 helps with energy levels and it is necessary for metabolizing fats and carbohydrates. Our body relies on B12 for the efficient conversion of carbohydrates and fatty acids to glucose-which is the fuel that the human body runs on. Studies have shown that Methylcobalamin the active form of Vitamin B-12) and the L Methyl Foliate (the active form of Folic Acid) are also extremely important in the forming of glutathione, the most prevalent antioxidant in our body which diminishes with age.

Low levels of B-12 are known to lead to premature dementia. In the USA many do not have enough B-12 yet they need it for memory and clarity of thought. At the end, all this science makes our B-12 complex very important for good health and especially helpful when on the eHCG diet program.

INGREDIENTS:
Serving Size: Adults: 3/4 of the dropper
(Hold under tongue for as long as possible or at least 30 seconds before swallowing.)

Servings per container: 30
Calories: 0
Carbohydrates: 0

Amount Per Serving %DV
Vitamin B12 (Methylcobalamin) 1000mcg 16.667%
Vitamin B6 (Pyridoxine) 2000mcg 110%
Folic Acid (L-Methyl Folate) 4000mcg 100%

Other Ingredients: Purified Active Water, Natural Flavors, Herbal
Active as a natural preservative

These statements have not been evaluated by the Food and Drug Administration.
Products and information on this site are not intended to diagnose, treat, cure or prevent and disease.

~Vitamin Wagon carries quality products at competitive prices~